Product info: Antibiotics - Doxycycline
Doxycycline: Doxycycline (VIBRAMYCIN) is a tetracycline antibiotic. It works by preventing the growth and spread of bacteria. Antibiotics will not work for colds, flu, or other viral infections. It fights bacteria in the body, including pneumonia and other respiratory tract infections. Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, periodontitis (gum disease), and anthrax (after inhalational exposure) and others. Doxycycline may also be used for other purposes not listed in this medication guide.
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Pharmacology
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Inhibits bacterial protein synthesis.
Pharmacokinetics
Absorption
Well absorbed. T max is 2 to 2.6 h (oral). C max is 2.6 mcg/mL (200 mg oral hyclate dose), 2.5 to 3.6 mcg/mL (100 to 200 mg IV dose). Absorption may be decreased by 20% when given with food or milk.
Distribution
Bound to plasma proteins. Crosses the placenta; excreted in breast milk.
Elimination
Approximately 40% excreted by the kidneys in 72 h. The t ? is 16 to 22 h.
Special Populations
Renal Function Impairment
Excretion by the kidneys may fall as low as 1% to 5% in 72 h in those with Ccr less than 10 mL/min.
Indications and Usage
Treatment of infections caused by susceptible strains of gram-positive and gram-negative bacteria (eg, Rickettsia , Mycoplasma pneumoniae ); treatment of trachoma and susceptible infections when penicillins are contraindicated; treatment of acute intestinal amebiasis; uncomplicated gonorrhea in adults; prophylaxis of malaria caused by Plasmodium falciparum ; anthrax (including inhalational anthrax); severe acne.
Periodontitis Tablet
Adjunct treatment to scaling and root planing to promote attachment level gain and reduce pocket depth.
Subgingival injection
For chronic adult periodontitis for a gain in clinical attachment, reduction in probing depth, and reduction in bleeding on probing.
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